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Implementation of the first stand-alone NAMs for eye hazard identification into OECD Guidelines: OECD GL 467 and TG 492B.
In the past decade, a number of Non-Animal Methods (NAMs) for predicting eye hazards of chemicals have been adopted as OECD Test Guidelines. However, to this date, no single NAM could completely replace the in vivo Draize eye test method due to the difficulty with predicting the middle category (i.e., eye irritation) for eye hazards. Studies have shown that this difficulty is linked to the variability and inconsistency within the results from the Draize eye test, which is used as reference data for evaluating the predictive capacity of the NAMs for eye hazard identification.

The newly adopted OECD GL 467 on Defined Approaches addresses this challenge and is the first stand-alone NAM based OECD Guideline. Defined approaches in OECD GL 467 use multiple information sources according to a fixed Data Interpretation Procedure (DIP) and allow for prediction of all eye hazard categories. OECD also recently adopted TG 492B, another stand-alone NAM based OECD Guideline.

OECD prepared this webinar to increase the awareness of these newly adopted guidelines for regulatory acceptance and to recognize the efforts of the organization as well as its stakeholders to enable 3R Principles for chemical hazard testing.

This webinar will be consisted of three parts on: 1) Draize eye test Reference Database (DRD), 2) OECD Guideline 467 on Defined Approaches for Serious Eye Damage and Eye Irritation and 3) OECD Test Guideline 492B on Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification.

Sep 27, 2022 02:00 PM in Paris

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