Join us on Thursday 25 February to discuss the scope, content, and use of the Test Guideline No. 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media and its accompanying Guidance Document. Further discussions will focus on the scope of the upcoming Test Guideline.
The increased production and wide usage of manufactured nanomaterials suggest a higher probability of finding them in the environment. Therefore, testing the dissolution rate and dispersion stability for toxicity assessment are of paramount importance for adequate hazard assessment.
To this extent, the OECD Test Guideline No. 318 describes a test procedure to gain information on dispersion stability of nanomaterials in simulated environmental media. An accompanying Guidance Document provides additional recommendations on dispersion stability measurements. The GD No. 318 gives interim guidance on how to determine dissolution of nanomaterials under environmental conditions and describes how these data can be used to guide further environmental testing. GD 318 also outlines some initial recommendations on how to extend TG 318 for testing heteroagglomeration of Manufactured Nanomaterials with environmental particles.
To complement these documents, a Test Guideline to determine the solubility and dissolution rate of nanomaterials in the aqueous environmental media is currently under development.